Lower respiratory infections (LRIs) are the foremost cause of infection-related mortality worldwide. Based on the real-world pathogen data of China, we provide Life-Stage-Specific Pathogen Spectra, Coinfection Networks, and Sex Disparities in Hospitalized Patients with Lower Respiratory Infections.
All samples analyzed using uniform tNGS testing for 28 common respiratory pathogens, ensuring consistent and comprehensive detection across all hospitals.
Evidence-based eight-group stratification system derived from real-world clinical pathogen spectra, minimizing within-group heterogeneity and maximizing clinical relevance.
We stratified hospitalized LRI patients into eight distinct age groups: infant (0-1), toddler (1-3), child (4-11), adolescent (12-17), young adult (18-38), middle-aged (39-61), elderly (62-81), and octogenarian (>81 years).
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Data-driven "risk map" for severe lower respiratory infection hospitalizations across China. By analyzing eight distinct life stages, we uncover significant variations in risk by age. Furthermore, we identified high-risk coinfection networks comprising 124 pathogen pairs. A key finding is that pathogens with more similar age distributions have a higher likelihood of coinfection. These insights are crucial for developing targeted prevention and clinical management strategies tailored to specific demographic groups..
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